Cyclodextrins　(CDs)　are　a　series　of　cyclic　oligosaccharides　formed　by　amylose　under　the　action　of　CD　glucosyltransferase　that　is　produced　by　Bacillus.　After　being　modified　by　polymerization,　substitution　and　grafting,　high　molecular　weight　cyclodextrin　polymers　(pCDs)　containing　multiple　CD　units　can　be　obtained.　pCDs　retain　the　internal　hydrophobic-external　hydrophilic　cavity　structure　characteristic　of　CDs,　while　also　possessing　the　stability　of　polymer.　They　are　a　class　of　functional　polymer　materials　with　strong　development　potential　and　have　been　applied　in　many　fields.　This　review　introduces　the　research　progress　of　pCDs,　including　the　synthesis　of　pCDs　and　their　applications　in　analytical　separation　science,　materials　science,　and　biomedicine.