A　novel　FeVO4/BiVO4　heterojunction　photocatalyst　was　synthesized　by　hydrothermal　method.　The　FeVO4/BiVO4　nanostructures　were　characterized　by　XRD,　SEM,　XPS,　UV-vis,　and　photoluminescence　spectroscopy.　The　effects　of　catalyst　dosage,　contaminant　concentration,　initial　hydrogen　peroxide　(H2O2)　concentration,　and　pH　value　on　the　degradation　of　levofloxacin　were　investigated　and　several　repeated　experiments　were　conducted　to　evaluate　the　stability　and　reproducibility.　The　optimized　process　parameters　were　used　for　mineralization　experiments.　Reactive　oxygen　species,　degradation　intermediates,　and　possible　catalytic　mechanisms　were　also　investigated.　The　results　showed　that　the　sonophotocatalytic　performance　of　the　FeVO4/BiVO4　heterojunction　catalyst　was　better　than　that　of　sonocatalysis　and　photocatalysis.　In　addition,　the　Type　II　heterojunction　formed　by　the　material　still　had　good　stability　in　the　degradation　of　levofloxacin　after　5　cycles.　The　possible　degradation　pathway　and　mechanism　of　levofloxacin　by　sonophotocatalysis　were　put　forward.　This　work　develops　new　sono-photo　hybrid　process　for　potential　application　in　the　field　of　wastewater　treatment.