The　rapid　emergence　of　drug-resistant　bacteria　has　raised　a　great　social　concern　together　with　the　impetus　for　exploring　advanced　antibacterial　ways.　NIR-triggered　antimicrobial　photodynamic　therapy　(PDT)　by　lanthanide-doped　upconversion　nanoparticles　(UCNP)　as　energy　donor　exhibits　the　advantages　of　high　tissue　penetration,　broad　antibacterial　spectrum　and　less　acquired　resistance,　but　is　still　limited　by　its　low　efficacy.　Now　we　designed　a　bio-inorganic　nanohybrid　and　combined　lysozyme　(LYZ)　with　UCNP-PDT　system　to　enhance　the　efficiency　against　resistant　bacteria.　Benefiting　from　the　rapid　adhesion　to　bacteria,　intelligently　bacteria-responsive　LYZ　release　and　synergistic　LYZ-PDT　effect,　the　nanoplatform　achieves　an　exceptionally　strong　bactericidal　capacity　and　conspicuous　bacteriostasis　on　methicillin-resistant　S.　aureus.　These　findings　pave　the　way　for　designing　efficiently　antibacterial　nanomaterials　and　provide　a　new　strategy　for　combating　deep-tissue　bacterial　infection.