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Abstract:
An asymmetric [3 + 2]-cycloaddition reaction of alpha,beta-unsaturated 2-acyl imidazoles with spirovinylcyclopropanyl-2-oxindoles catalyzed synergistically by an achiral palladium(0) catalyst and a chiral-at-metal rhodium(III) complex has been developed. A series of biologically important 3-spirocyclopentane-2-oxindoles with four contiguous stereocenters were synthesized in high yields (up to 99%) with excellent stereoselectivities (up to 99% ee, 20:1 dr).
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ORGANIC LETTERS
ISSN: 1523-7060
Year: 2020
Issue: 24
Volume: 22
Page: 9539-9544
6 . 0 0 5
JCR@2020
4 . 9 0 0
JCR@2023
ESI HC Threshold:160
JCR Journal Grade:1
CAS Journal Grade:1
Cited Count:
WoS CC Cited Count: 23
SCOPUS Cited Count:
ESI Highly Cited Papers on the List: 0 Unfold All
WanFang Cited Count:
Chinese Cited Count:
30 Days PV: 0
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