Peptides　derived　from　crimson　snapper　scales　(CSSPs)　were　reported　to　possess　excellent　free　radical　scavenging　activities　in　vitro.　In　present　study,　the　anti-aging　and　anti-oxidative　stress　effects　of　CSSPs　were　evaluated　in　Drosophila　melanogaster　models.　Results　showed　that　the　addition　of　CSSPs　in　the　diets　of　normal　Drosophila　could　effectively　extend　their　lifespan　and　improve　the　motor　ability　of　aged　Drosophila.　Moreover,　CSSPs　could　protect　Drosophila　from　oxidative　damage　induced　by　H2O2,　paraquat　and　UV　irradiation.　The　extension　of　lifespan　was　found　to　be　associated　with　the　effects　of　CSSPs　in　improving　the　antioxidant　defense　system　of　Drosophila,　manifesting　as　the　reduction　of　oxidation　products　MDA　and　PCO,　the　elevated　activities　of　T-SOD,　CAT　and　GSH-Px,　and　the　upregulated　expression　of　antioxidant　related　genes　after　CSSPs　supplemented.　Furthermore,　CSSPs　at　6　mg/mL　significantly　downregulated　mTOR　signaling　pathway　and　activated　autophagy　in　aged　male　Drosophila,　and　the　inhibition　on　mTOR　activation　was　probably　mediated　by　the　antioxidant　effects　of　CSSPs.　Our　findings　suggest　that　CSSPs　have　the　potential　in　making　dietary　supplements　against　natural　aging　and　oxidative　stress　in　organisms.