With　the　aging　problems　increasing,　the　discovery　of　anti-aging　compounds　has　become　a　popular　research　direction.　Accumulation　of　free　radicals　and　the　consequent　oxidative　stress　are　the　chief　culprit　of　aging.　Given　this,　cultured　crocodile　meat　peptides-Maillard　reaction　product　(CMP-MRP)　with　remarkable　antioxidant　activity　was　obtained　via　Maillard　reaction　of　cultured　crocodile　meat　hydrolysates　and　xylose.　The　antioxidant　activity　in　vitro　and　anti-aging　activity　in　vivo　of　CMP-MRP　were　investigated.　Results　indicated　that　the　lifespan　and　the　athletic　ability　of　Drosophila　were　significantly　improved　after　the　administration　of　CMP-MRP　in　natural　aging,　H2O2-　and　paraquat-induced　models.　Furthermore,　the　antioxidant　enzyme　activities　of　Drosophila　treated　with　CMP-MRP　were　enhanced　while　the　levels　of　malondialdehyde　(MDA)　and　protein　carbonyl　(PCO)　were　reduced　in　three　Drosophila　models.　With　the　supplement　of　5　mg/mL　CMP-MRP　in　natural　aging　Drosophila　model,　the　maximum　lifespan　increased　from　61　days　to　73　days,　athletic　ability　raised　by　95.45%,　MDA　and　PCO　reduced　by　52.72%　and　47.43%,　respectively.　Taken　together,　CMP-MRP　exhibited　outstanding　antioxidant　and　anti-aging　capacities　in　Drosophila　models,　suggesting　that　CMP-MRP　possesses　great　potential　in　the　health　food　and　biomedicine　fields　as　a　food-derived　anti-aging　agent.