The　gap　between　supply　and　demand　of　propylene　has　become　more　and　more　evident,　because　of　a　large　consumption　of　the　downstream　products　derived　from　propylene.　Propane　dehydrogenation　(PDH)　constitutes　an　important　alternative　for　the　production　of　propylene,　and　thus　considerable　attention　has　been　paid　to　the　development　of　eco-friendly　and　cost-efficient　catalysts　for　this　process.　Herein,　we　discover　that　the　Sn-Beta　zeolite　with　Lewis　acid　sites　can　activate　the　C-H　bond,　and　exhibits　high　catalytic　performance　in　the　PDH.　XRD,　STEM,　and　XPS　characterizations　confirm　that　Sn　species　are　incorporated　into　the　zeolite　framework,　and　H-2-TPR　suggests　that　there　is　a　strong　interaction　between　Sn　species　and　zeolite　framework.　It　is　found　that　the　Lewis　acid　is　the　active　site　for　dehydrogenation　reaction,　and　the　Bronsted　acid　is　responsible　for　cracking　reaction.　The　dehydrogenation　rate/cracking　rate　is　positively　proportional　to　the　L/B　ratio,　and　a　high　L/B　ratio　is　beneficial　for　the　propane　dehydrogenation　reaction.　The　Na-Sn-Beta-30　catalyst　possessing　the　highest　amount　of　Lewis　acid　but　the　lowest　Bronsted/Lewis　ratio,　exhibits　the　best　performance　in　the　PDH,　which　delivers　propane　conversion　of　40%　and　propylene　selectivity　of　92%.　Most　importantly,　these　Sn-Beta　zeolites　are　extremely　stable　without　any　detectable　deactivation　under　the　harsh　reaction　condition　for　72　h.　Density　functional　theory　calculations　reveal　that　both　Sn　and　adjacent　O　atom　or　OH　group　cooperatively　act　as　the　active　sites.　The　PDH　occurs　through　the　direct　reaction　mechanism　in　which　hydrogen　molecule　is　produced　by　the　direct　coupling　of　H　atom　of　primary　C3H7　motif　with　the　Bronsted　proton　in　closed　sites　or　the　proton　of　water　in　open　sites.　It　seems　that　open　sites　are　more　reactive　than　the　closed　ones,　and　the　intrinsic　enthalpy　barriers　are　calculated　to　be　242　-　301　kJ/mol　depending　on　the　hydroxylation　extents.　These　efficient　Sn-Beta　zeolites　could　provide　a　new　possibility　for　the　development　of　a　new　generation　of　PDH　catalysts　with　a　high　stability　for　the　production　of　propylene.　(C)　2021　Elsevier　Inc.　All　rights　reserved.