The　enantioselective　introduction　of　gem-difluorinated　carbonyl　(i.　e.　alpha,alpha-difluoro　carbonyl)　moieties　into　organic　structures　is　a　synthetically　valuable　but　highly　challenging　approach.　During　the　past　decades,　continuous　efforts　have　been　made　for　the　developments　of　synthetic　strategies　for　constructing　C(sp(3))-CF2COR　chiral　centers　with　high　levels　of　enantioselectivities.　This　review　summarizes　and　discusses　the　recent　advance　in　the　enantioselective　construction　of　gem-difluorinated　carbonyl　moieties,　which　are　organized　according　to　the　reaction　categories.