The　antibiotics　pollution　has　currently　captured　increasing　concerns　due　to　its　potential　hazards　to　the　environment　and　human　health.　The　development　of　efficient　and　viable　techniques　for　the　removal　of　antibiotics　is　one　of　the　research　hotspots　in　fields　of　wastewater　treatment　and　pharmaceutical　industry.　Although　the　photodegradation　of　antibiotics　is　widely　studied,　the　evolution　and　toxicity　of　degradation　intermediates　have　been　rarely　documented.　Herein,　Pt　nanoparticles　(NPs)　decorated　BiVO4　nanosheets　(Pt/BiVO4　NSs)　that　exhibit　excellent　tetracycline　(TC)　photodegradation　activity　and　stability　have　been　prepared.　Especially,　the　TC　degradation　efficiency　reaches　ca.　88.5%　after　60　min　under　visible　light　irradiation,　which　is　superior　to　most　of　the　metal　loaded　two–dimensional　photocatalysts　reported　hitherto.　The　excellent　photocatalytic　activity　is　attributable　to　the　enhanced　light　absorption　capacity　and　charge　separation　efficiency　in　Pt/BiVO4　NSs.　h+,　•O2−　and　•OH　are　the　main　active　species　for　TC　degradation,　resulting　in　three　possible　degradation　pathways.　Furthermore,　we　first　verify　that　TC　solutions　treated　by　Pt/BiVO4　NSs　are　harmless　to　Escherichia　coli　K–12　and　various　bacteria　in　natural　rivers,　which　would　not　stimulate　Escherichia　coli　to　produce　antibiotics　resistance　genes　(ARGs).　This　work　develops　an　environmentally　friendly　photodegradation　strategy　using　Pt/BiVO4　NSs　with　potentials　for　efficient　remediation　of　antibiotics　pollution　in　wastewater.　©　2021　Elsevier　B.V.