The　project　studied　the　occurrence,　fate,　and　seasonal　variation　of　14　antibiotics,　from　five　wastewater　treatment　plants　(WWTPs)　in　Shanghai.　The　results　indicated　that　ofloxacin,　sulfamethoxazole,　and　oxytetracycline　were　the　predominant　antibiotics,　with　maximum　concentrations　of　1208.20,　959.13,　and　564.30　ng/L　in　influents,　while　916.88,　106.60,　and　337.81　ng/L　in　effluents,　respectively.　The　level　of　antibiotics　in　WWTPs　obviously　varied　with　seasonal　changes,　and　higher　detectable　frequencies　and　concentrations　were　found　in　winter.　The　daily　mass　loads　per　capita　of　amoxicillin,　enrofloxacin,　and　oxytetracycline　in　the　study　were　all　higher　than　those　in　other　regions/countries,　such　as　Hong　Kong,　Australia,　and　Italy.　The　elimination　of　antibiotics　through　these　WWTPs　was　incomplete,　and　a　wide　range　of　removal　efficiencies　during　the　different　treatment　process　and　seasons　were　observed　(-500.56　to　100　%　in　winter　and　-124.24　to　94.21　%　in　summer).　Sulfonamides　were　relatively　easy　to　be　removed　in　WWTPs　and　the　ultraviolet　(UV)　process　can　effectively　improve　the　removal　efficiency.　Risk　assessment　of　antibiotics　in　effluents　was　estimated.　Only　AMOX＇s　hazard　quotient　(HQ)　was　higher　than　0.01.　Even　though　the　environmental　risks　in　the　study　were　estimated　to　be　low,　the　potential　negative　effects　on　aquatic　ecosystems　should　call　our　attention　as　continually　discharge　in　the　long　term.