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author:

Zhang, Peixia (Zhang, Peixia.) [1] | Zhang, Lu (Zhang, Lu.) [2] | Wang, Jun (Wang, Jun.) [3] | Zhu, Lisheng (Zhu, Lisheng.) [4] | Li, Ziying (Li, Ziying.) [5] | Chen, Haijun (Chen, Haijun.) [6] | Gao, Yu (Gao, Yu.) [7]

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EI

Abstract:

The clinical efficacy of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs)-based targeted molecular therapies (TMT) is inevitably hampered by the development of acquired drug resistance in non-small cell lung cancer (NSCLC) treatment. Sonodymanic therapy (SDT) is a promising new cancer treatment approach, but its effects are restricted by tumor hypoxia. Herein, a nanoplatform fabricated by erlotinib-modified chitosan loading sonosensitizer hematoporphyrin (HP) and oxygen-storing agent perfluorooctyl bromide (PFOB), namely CEPH, was developed to deliver HP to erlotinib-sensitive cells. CEPH with ultrasound could alleviate hypoxia inside the three-dimensional multicellular tumor spheroids, suppress NSCLC cell growth under normoxic or hypoxic condition, and enhance TMT/SDT synergistic effects through elevated production of reactive oxygen species, decrease of mitochondrial membrane potential, and down-regulation of the expression of the proteins EGFR, p-EGFR, and HIF-1α. Hence, CEPH could be a potential nanoplatform to improve the efficacy of oxygen-dependent SDT and overcome hypoxia-induced TMT resistance for enhanced synergistic TMT/SDT. © 2021 Elsevier Ltd

Keyword:

Amino acids Biological organs Cell proliferation Chitosan Diseases Mitochondria Oxygen Tumors

Community:

  • [ 1 ] [Zhang, Peixia]Cancer Metastasis Alert and Prevention Center, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou; Fujian; 350108, China
  • [ 2 ] [Zhang, Lu]Cancer Metastasis Alert and Prevention Center, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou; Fujian; 350108, China
  • [ 3 ] [Wang, Jun]Cancer Metastasis Alert and Prevention Center, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou; Fujian; 350108, China
  • [ 4 ] [Zhu, Lisheng]Cancer Metastasis Alert and Prevention Center, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou; Fujian; 350108, China
  • [ 5 ] [Li, Ziying]Cancer Metastasis Alert and Prevention Center, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou; Fujian; 350108, China
  • [ 6 ] [Chen, Haijun]Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou; Fujian; 350108, China
  • [ 7 ] [Gao, Yu]Cancer Metastasis Alert and Prevention Center, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou; Fujian; 350108, China

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Source :

Carbohydrate Polymers

ISSN: 0144-8617

Year: 2021

Volume: 274

1 0 . 7 2 3

JCR@2021

1 0 . 7 0 0

JCR@2023

ESI HC Threshold:117

JCR Journal Grade:1

CAS Journal Grade:1

Cited Count:

WoS CC Cited Count: 0

SCOPUS Cited Count: 25

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 3

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