Peritendinous　adhesion,　secondary　to　the　repair　surgery　of　tendon　rupture　or　injury,　is　one　of　the　most　common　causes　of　reoperation,　owing　to　the　proliferation　of　fibrous　tissue　and　excessive　collagen　synthesis　caused　by　the　residing　inflammatory　cells.　In　this　study,　a　smart　oxidative　stress-responsive　electrospun　polyester　membrane　(EPM)　was　fabricated　as　both　physical　barrier　and　reservoir　of　curcumin/celecoxib　(CUR/CEL)　to　prevent　peritendinous　adhesion.　The　multicomponent　EPM　was　designed　to　release　the　encapsulated　drugs　in　response　to　oxidative　stress　of　the　local　microenvironment　induced　by　inflammation.　Specifically,　sulfides　in　the　EPM　were　able　to　react　with　reactive　oxygen　species　(ROS)　and　become　hydrophilic　sulfoxide　or　sulfone　to　accelerate　the　release　rate　of　drugs　and　regulate　oxidative　stress　level　in　the　inflammatory　site　intelligently.　The　oxidation-sensitive　multicomponent　EPM　loaded　with　CUR　and　CEL　was　tested　for　anti-adhesion　capacity　in　vitro　and　in　vivo.　An　excellent　ROS-sensitive　degradation　behavior　and　good　cytocompatibility　with　cell　viability　of　above　85%　were　presented　with　the　fabricated　EPM.　The　CUR-　or　CEL-loaded　EPM　possessed　a　better　anti-adhesion　ability　compared　with　EPM　without　the　drugs.　Nevertheless,　they　were　inferior　to　the　EPM　simultaneously　loaded　with　both　drugs,　where　the　adhesion　rate　and　fibrous　adhesion　number　in　the　EPM+CUR/CEL　group　were　close　to　extremely　low　values　of　about　zero,　demonstrating　that　CUR　and　CEL　could　synergistically　prevent　peritendinous　adhesion.　More　interestingly,　the　multicomponent　EPM　was　able　to　react　with　the　local　oxidative　stress,　leading　to　a　smart　and　sustained　behavior　of　releasing　approximately　80%　of　the　drug　within　20　days.　Overall,　the　smart　multicomponent　EPM　offers　a　promising　barrier　strategy　to　prevent　peritendinous　adhesion.　©　2021　Elsevier　B.V.