Red　blood　cells　(RBCs)　have　recently　emerged　as　promosing　candidates　for　cancer　treatment　in　terms　of　relieving　tumor　hypoxia　and　inducing　oxidative　damage　against　cancer　cells,　but　they　are　still　far　from　satisfactory　due　to　their　limited　oxygen　transport　and　reactive　oxygen　spe-cies　generation　rate　in　tumor　tissue.　Herein,　artificial　RBCs　(designated　FTP@RBCM)　with　radical　storm　production　ability　were　developed　for　oncotherapy　through　multidimensional　reactivity　pathways　of　Fe-proto-porphyrin-based　hybrid　metal-organic　frameworks　(FTPs,　as　the　core),　including　photodynamic/chemodynamic-like,　catalase-like　and　glutathione　peroxidase-like　activities.　Meanwhile,　owing　to　the　advantages　of　long　circulation　abilities　of　RBCs　provided　by　their　cell　membranes　(RBCMs),　FTP　with　a　surface　coated　with　RBCMs　(FTP@RBCM)　could　enormously　accumulate　at　tumor　site　to　achieve　remarkably　enhanced　therapeutic　efficiency.　Intriguingly,　this　ROS-mediated　dynamic　therapy　was　demonstrated　to　induce　acute　local　inflammation　and　high　immunogenic　cancer　death,　which　evoked　a　systemic　antitumor　immune　response　when　combined　with　the　newly　identified　T　cell　immunoglobulin　and　mucin-containing　molecule　3　(Tim-3)　checkpoint　blockade,　leading　to　not　only　effective　elimination　of　primary　tumors　but　also　an　abscopal　effect　of　growth　suppression　of　distant　tumors.　Therefore,　such　RBC-mimic　nanocatalysts　with　multidimensional　catalytic　capacities　might　provide　a　promising　new　insight　into　synergistic　cancer　treatment.