This　article　proposes　a　high-level　engineering　guide　to　develop　an　integrated　system　model　for　power　quality　analysis　in　electrical　submersible　pump　(ESP)　applications　with　variable　frequency　drives　(VFDs).　Such　analyses　are　troublesome　in　the　industry　due　to　the　complexity　of　these　systems.　In　this　article,　simple　steps　to　perform　system　integration　analyses　of　such　arrangements,　including　torsional　analysis,　are　developed.　A　simplified　VFD-ESP　model　suitable　for　coupled　electrical　and　mechanical　analysis　in　steady　state　is　proposed　in　all　their　configurations　of　practical　interest.　Such　a　model　can　be　easily　implemented　in　common　simulation　software,　significantly　reducing　engineering　efforts　for　implementation　and　analysis.　The　focus　of　the　proposed　model　is　the　prediction　of　ESP　failures　that　might　result　from　a　poor　power　quality　caused　by　VFDs.　Analytical　expressions　of　different　types　of　harmonics　in　these　systems,　as　well　as　their　accurate　locations　in　the　frequency　domain,　including　their　interharmonics　and　common-mode　harmonics,　are　derived　for　this　purpose.　The　effectiveness　of　the　proposed　model　is　verified　through　offline　and　real-time　hybrid　simulation　results.　Finally,　a　comparison　between　simulation　results　obtained　using　the　proposed　model　and　measurements　collected　on　a　down-scale　laboratory　prototype　is　carried　out　to　demonstrate　the　accuracy　of　the　suggested　modeling　approach.