Inflammatory　responses　of　nucleus　pulposus　(NP)　can　induce　imbalanced　anabolism　and　catabolism　of　extracellular　matrix,　and　the　cytosolic　dsDNA　accumulation　and　STING-NE-kappa　B　pathway　activation　found　in　NP　inflammation　are　considered　as　fairly　important　cause　of　intervertebral　disc　(IVD)　degeneration.　Herein,　we　constructed　a　siSTING　delivery　hydrogel　of　aldehyde　hyaluronic　acid　(HA-CHO)　and　poly(amidoamine)　PAMAM/siRNA　complex　to　intervene　the　abnormal　STING　signal　for　IVD　degeneration　treatment,　where　the　formation　of　dynamic　Schiff　base　bonds　in　the　system　(siSTING@HPgel)　was　able　to　overcome　the　shortcomings　such　as　low　cellular　uptake,　short　half-life,　and　rapid　degradation　of　siRNA-based　strategy.　PAMAM　not　only　formed　complexes　with　siRNA　to　promote　siRNA　transfection,　but　also　served　as　dynamic　crosslinker　to　construct　hydrogel,　and　the　injectable　and　self-healing　hydrogel　efficiently　and　steadily　silenced　STING　expression　in　NP　cells.　Finally,　the　siSTING@HPgel　significantly　eased　IVD　inflammation　and　slowed　IVD　degeneration　by　prolonging　STING　knockdown　in　puncture-induced　IVD　degeneration　rat　model,　revealing　that　STING　pathway　was　a　therapeutic　target　for　IVD　degeneration　and　such　novel　hydrogel　had　great　potential　for　being　applied　to　many　other　diseases　for　gene　delivery.