Acrylic　liquid-crystal　resin　(ALCR)　was　synthesized　in　three　steps　using　4-hydroxybenzoate　4-carboxylic　phenyl　ester　as　the　mesocrystalline　unit.　The　structure,　heat　resistance,　and　liquid–crystal　properties　of　the　ALCR　were　systematically　investigated.　The　ALCR　was　used　to　produce　new　3D　printing　inks,　which　exhibited　good　fluidity　and　rapid　photopolymerization　ability　to　meet　the　rheological　prerequisites　of　3D　printing　ink.　Compared　with　commercial　ink,　the　initial　decomposition　temperature　increased　from　304.9　to　334.3　°C,　the　glass　transition　temperature　increased　from　74.8　to　89.8　°C,　and　the　storage　modulus　increased　from　1107.6　to　2230.6　MPa　for　the　ALCR　inks.　The　tensile　strength,　elongation　at　break,　flexural　strength,　impact　strength,　and　hardness　of　an　ink　containing　20%　ALCR　were　improved　to　65.3　MPa,　17.3%,　103.9　MPa,　4.8　kJ　m−2,　and　77.1　HD,　respectively,　corresponding　to　147.4%,　174.7%,　207.4%,　171.4%,　and　106.6%　of　the　values　for　commercial　ink.　These　results　indicate　that　ALCR　can　effectively　improve　the　mechanical　properties　of　3D-printed　products　in-situ.　This　is　because　the　liquid-crystal　molecules　in　the　product　stack　to　form　mesogenic　domains.　When　subjected　to　an　external　force,　these　mesogenic　domains　exploit　their　own　orientation,　cross-linking,　and　high-strength　characteristics　to　effectively　improve　the　mechanical　properties　of　the　product.　©　2022　The　Authors