Structurally　stable,　multifunctional　ion-copolymer　composites　with　enhanced　ionic,　hydrophilic　and　hydrophobic　properties　are　developed　utilizing　multimodal　materials.　These　hyperbranched　polymeric　composites　function　as　strong　supports　in　multifunctional　applications.　The　integration　of　zwitterionic　block　copolymers　of　deep　eutectic　solvent　(ZDES)　and　deposited　magnetic　nanospheres　(Fe3O4@PCL-ZDES)　promotes　the　formation　of　a　multiple　interaction　platform.　Ion-copolymer　composites　are　formed　via　non-covalent　immobilization　using　citric　acid　and　choline　chloride　as　hydrogen　donors　and　acceptors,　affording　numerous　amphipathic　zwitterionic　composites.　The　ion-copolymer　composite　exhibits　outstanding　selectivity　for　glycoprotein　in　the　presence　of　diverse　proteins,　which　is　comparable　to　those　of　majority　hydrophilic　chromatographic　materials.　Furthermore,　these　zwitterionic　magnetic　nanospheres　preserve　their　highly　selective　characteristics　towards　immunoglobulin,　as　evidenced　by　their　enhanced　hydrophilic-hydrophobic　properties.　This　paper　presents　typical　amphipathic　nanospheres,　as　well　as　the　increased　potential　of　zwitterionic　block　copolymers　as　smart　separation　materials　for　glycoproteins　in　complex　biological　samples.　©　the　Partner　Organisations.