Varieties　of　contrast　agents　have　been　developed　for　photoacoustic　(PA)　and　ultrasound　(US)　imaging　of　cancers　in　vivo.　However,　access　of　traditional　contrast　agents　into　the　sites　of　tumors　has　been　principally　through　passive　infiltration　without　any　external　force,　preventing　their　deep　penetration　into　the　tissues　of　the　tumors,　and　hindering　the　use　of　PA　and　US　for　deep　tumor　imaging.　The　concept　of　micro/nanomotors　has　been　the　focus　of　increasing　attention　as　active　theranostic　agents　due　to　their　active　movement　in　particular　fluids,　thereby　conducting　assigned　tasks.　Herein,　US-propelled　Janus　mesoporous　SiO2　partially　coated　gold　nanorods　(Au　NR-mSiO2)　were　fabricated　for　deep　tumor　NIR-II　PA　imaging　and　synergistic　sonodynamic-gas　therapy.　Following　US　irradiation,　2,2-azobis[2-(2-imidazolin-2-yl)　propane]　dihydrochloride　(AIPH)　loaded　in　mSiO2　(Au　NR-mSiO2/AIPH)　generated　N2　microbubbles　with　high　efficiency　to　achieve　nanomotor　drive.　Due　to　the　deep　penetration　of　US,　the　nanomotors　exhibited　a　capability　to　travel　deep　within　sites　of　tumors,　providing　enhanced　PA/US　imaging　inside　the　tumors.　Furthermore,　the　nanomotor　based　cancer　therapy　was　demonstrated　through　synergistic　N2　gas　and　sonodynamic　therapy.　The　US-propelled　nanomotors　demonstrated　a　novel　strategy　for　the　simultaneous　PA/US　dual　imaging　deep　within　tumor　tissues　and　precise　therapy　of　large　tumors.　[Figure　not　available:　see　fulltext.]　©　2021,　Science　China　Press　and　Springer-Verlag　GmbH　Germany,　part　of　Springer　Nature.