This　article　investigates　the　influence　of　different　nanofluid　distributions　on　the　treatment　temperature　by　considering　a　homogeneous　distribution　of　magnetic　nanoparticles　(MNPs).　Two　distributions　are　observed　in　experimental　images　and　modeled　by　the　proposed　method　in　this　article.　Meanwhile,　the　effect　of　nanofluid　diffusion　on　the　concentration　distribution　is　further　studied.　In　addition,　the　difference　of　temperature-based　on　the　blood　perfusion　rate　and　the　traditional　quantitative　perfusion　rate　is　also　considered.　The　treatment　effect　in　this　study　is　evaluated　by　the　cumulative　equivalent　minutes　at　43　(CEM43)　from　the　perspective　of　the　thermal　iso-effect　dose,　which　is　directly　related　to　the　treatment　temperature　distribution.　Simulation　results　demonstrate　that　the　nanofluid　diffusion　has　positive　effect　on　the　uniformity　degree　of　nanofluid　distribution　inside　tumor　region,　while　it　has　less　effect　on　the　ultimate　treatment　temperature　if　individual　critical　power　dissipations　of　MNPs.　©　2021,　Science　Press.　All　right　reserved.