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Abstract:
Synergistic antibacterial effect is a promising way to overcome the challenge of microbial contamination in food. In this study, we detected the synergistic interactions of nisin and carvacrol. The MIC of nisin and carvacrol against S. aureus were 60 and 125 mu g/mL, respectively. The FICI and FBCI were 0.28125 and 0.09375, which suggested that the nisin/carvacrol combination presented synergistic antibacterial effect against S. aureus. The antibacterial activity of nisin/carvacrol combination was much higher than their individuals and the dose of antibacterials was obviously reduced. The combination could completely kill S. aureus within 8 h, accelerate the destruction of cell membrane, and inhibit formation of biofilm. Under the intervention of nisin, more CAR could enter cell to hunt intracellular targets, leading to an increase in intracellular antibacterial level. Besides, in the storage of pasteurized milk, the combinational treatment successfully inhibited microbial reproduction at 25?& nbsp;and 4?. Thus, the combination of nisin and carvacrol was a potential synergistic strategy for food preservation.
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FOOD CHEMISTRY
ISSN: 0308-8146
Year: 2022
Volume: 380
8 . 8
JCR@2022
8 . 5 0 0
JCR@2023
ESI Discipline: AGRICULTURAL SCIENCES;
ESI HC Threshold:48
JCR Journal Grade:1
CAS Journal Grade:1
Cited Count:
WoS CC Cited Count: 75
SCOPUS Cited Count: 55
ESI Highly Cited Papers on the List: 13 Unfold All
WanFang Cited Count:
Chinese Cited Count:
30 Days PV: 0
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