Just　as　the　heterojunctions　in　physics,　donor-acceptor　(D-A)　heterostructures　are　an　emerging　class　of　photoactive　materials　fabricated　from　two　semiconductive　components　at　the　molecular　level.　Among　them,　D-A　hybrid　heterostructures　from　organic　and　inorganic　semiconductive　components　have　attracted　extensive　attention　in　the　past　decades　due　to　their　combined　advantages　of　high　stability　for　the　inorganic　semiconductors　and　modifiability　for　the　organic　semiconductors,　which　are　particularly　beneficial　to　efficiently　achieve　photoinduced　charge　separation　and　transfer　upon　irradiations.　In　this　review,　by　analogy　with　the　heterojunctions　in　physics,　a　definition　of　the　D-A　heterostructures　and　their　general　design　and　synthetic　strategies　are　given.　Meanwhile,　the　D-A　hybrid　heterostructures　are　focused　on　and　their　recent　advances　in　potential　applications　of　photochromism,　photomodulated　luminescence,　and　photocatalysis　summarized.