Composite　girders　with　corrugated　steel　webs　and　concrete-filled　steel　tubular　(CSW-CFST)　truss　chords　are　a　new　type　of　structure　and　have　been　used　in　bridges.　To　study　the　fatigue　performance　of　these　composite　girders,　model　tests　and　numerical　analysis　were　conducted,　and　the　results　compared　with　those　for　composite　girders　with　corrugated　steel　webs　and　steel　tubular　(CSW-ST)　truss　chords.　The　results　indicated　that　concrete-filling　the　chords　constrained　chord　radial　deformation　and　relieved　hot-spot　stress　in　the　intersecting　weld　zones　of　composite　girders　with　CSW-ST　truss　chords　by　18.5-60.1%.　The　crack　growth　rates　along　both　depth　and　length　directions　in　composite　girders　with　CSW-CFST　truss　chords　were　lower　than　those　of　composite　girders　with　CSW-ST　truss　chords　during　the　crack　propagation　and　failure　stages.　Under　the　same　fatigue　load,　concrete-filling　the　chords　increased　the　fatigue　life　of　composite　girders　with　CSW-ST　truss　chords　by　61.5%.　Under　the　condition　that　there　is　no　fatigue　design　S-N　curve,　the　fatigue　design　S-N　curve　given　in　API　can　be　used　to　evaluate　the　fatigue　life　of　composite　girders　with　CSW-CFST　truss　chords　with　a　deviation　of　less　than　17.4%.