A　critical　technological　roadblock　to　the　widespread　adoption　of　proton-exchange　membrane　fuel　cells　is　the　development　of　highly　active　and　durable　platinum-based　catalysts　for　accelerating　the　sluggish　oxygen　reduction　reaction,　which　has　largely　relied　on　anecdotal　discoveries　so　far.　While　the　oxygen　binding　energy　Delta　E-O　has　been　frequently　used　as　a　theoretical　descriptor　for　predicting　the　activity,　there　is　no　known　descriptor　for　predicting　durability.　Here　we　developed　a　binary　experimental　descriptor　that　captures　both　the　strain　and　Pt　transition　metal　coupling　contributions　through　X-ray　absorption　spectroscopy　and　directly　correlated　the　binary　experimental　descriptor　with　the　calculated　Delta　E-O　of　the　catalyst　surface.　This　leads　to　an　experimentally　validated　Sabatier　plot　to　predict　both　the　catalytic　activity　and　stability　for　a　wide　range　of　Pt-alloy　oxygen　reduction　reaction　catalysts.　Based　on　the　binary　experimental　descriptor,　we　further　designed　an　oxygen　reduction　reaction　catalyst　wherein　high　activity　and　stability　are　simultaneously　achieved.