Ciprofloxacin　(CIP)　as　an　anti-inflammatory　drug　is　frequently　detected　in　various　water　resources.　Recently,　Sulfate　Radical-based　advanced　oxidation　processes　with　manganese　oxides　have　been　recognized　as　a　highly　effective　method　for　CIP　degradation.　Herein,　Ε-MnO2　was　obtained　through　a　convenient　drying　process.　After　different　atmospheric　treatments,　MnO　and　Mn2O3　were　fabricated　for　subsequent　degradation　experiments.　The　results　show　that　MnO　exhibits　better　catalytic　activity　than　Mn2O3,　with　high　removal　efficiency　of　almost　84.3%　for　CIP.　Quenching　test　and　electron　paramagnetic　resonance　spectra　confirm　that　1O2　is　the　dominant　species　during　reaction,　while　·OH　and　SO4·-　play　a　supporting　role.　A　related　discussion　about　the　role　of　valence　states　of　Mn　and　oxygen　vacancies　is　presented,　which　can　provide　a　theoretical　basis　for　further　development　of　Mn/peroxymonosulfate　system.　©　2022　Elsevier　Ltd