Supermacroporous　hydrogels　have　attracted　wide　concern　due　to　their　comfort　and　breathability　in　wearable　health-monitoring　applications.　Size　controllable　supermacroporous　structure　and　excellent　mechanical　properties　are　the　most　important　for　its　application.　However,　they　are　normally　fabricated　by　the　cryogelation　method,　which　is　difficult　to　control　pore　size　and　maintain　flexibility.　Here,　yeast　fermentation-inspired　gelatin　hydrogels　with　a　controllable　supermacroporous　structure　and　excellent　mechanical　properties　were　fabricated　for　the　first　time.　The　pore　size　can　be　controlled　by　adjusting　the　content　of　glucose　and　yeast,　the　ratio　of　glucose　to　yeast,　fermentation　time,　and　gelatin　content　during　fermentation.　The　hydrogels　demonstrated　a　controllable　pore　size　range　from　100　to　400　μm　and　rapid　swelling　characteristics.　The　mechanical　properties　were　maintained　by　soaking　ammonium　sulfate　solution　for　12　h,　showing　maximum　tensile　and　compressive　strains　over　300　and　99%,　respectively.　This　novel　approach　can　be　easily　applied　to　the　preparation　of　supermacroporous　and　high　ductility　hydrogels　under　mild　conditions.　Furthermore,　conductive　hydrogels　combined　supermacroporous　structures　with　conductive　polyaniline　and　reduced　oxidized　graphene,　and　silver　nanowires　were　prepared　as　wearable　flexible　sensors.　The　obtained　sensors　maintain　well-distributed　porosity,　breathability,　and　mechanical　flexibility,　also　showing　excellent　conductivity　of　2.4　S　m-1.　Finally,　the　sensors　were　successfully　applied　to　detect　physiological　signals　and　human-computer　interaction.　©　2022　American　Chemical　Society.　All　rights　reserved.