Multidrug-resistant　bacteria　infections　frequently　occur　in　wound　care　due　to　the　excessive　use　of　antibiotics.　It　can　cause　scar　formation,　wound　closure　delay,　multiple　organ　failure,　and　high　mortality.　Here,　a　double　network　hydrogel　with　injectability,　hemostasis,　and　antibacterial　activity　was　developed　to　prompt　multidrug-resistant　bacteria　infected　wound　healing.　The　double　network　hydrogel　is　composed　of　gelatin　methacryloyl　(GelMA),　oxidized　dextran　(ODex),　-polylysine　(EPL),　and　bacitracin,　and　formed　through　the　Schiff-base　and　UV-initiated　crosslinking　reaction.　The　injectable　hydrogel　with　an　adhesion　effect　could　adapt　to　the　irregular　shape　of　the　wound　and　possesses　good　hemostatic　ability.　The　hydrogel　presents　good　flexibility　and　rapid　resilience　due　to　its　double　network　structure,　and　it　can　prompt　cell　proliferation　and　migration.　In　particular,　the　hydrogel　has　broad-spectrum　in　vitro　antimicrobial　activities　against　S.　aureus,　E.　coli,　and　methicillin-resistant　S.　aureus　(MRSA),　and　disrupts　E.　coli　and　MRSA　biofilms.　In　vivo　results　demonstrated　that　the　hydrogel　can　completely　heal　MRSA-infected　wound　in　rats　within　15　days,　through　inhibiting　the　growth　of　bacteria,　accelerating　skin　tissue　reepithelialization,　collagen　deposition,　and　angiogenesis,　as　well　as　adjusting　the　expression　of　CD31,　α-SMA,　and　TNF-α.　The　findings　of　this　study　suggest　that　the　presented　hydrogel　could　enhance　multidrug-resistant　bacteria　infected　wound　healing　and　mitigate　antimicrobial　resistance.　©　2022　The　Royal　Society　of　Chemistry