In　order　to　enhance　the　catalytic　activity　of　Pd-based　catalysts　in　the　electrooxidation　of　ethylene　glycol,　CoO-NiO　binary　oxides　were　designed　and　synthesized　as　supports　for　Pd　nanoparticles.　The　physicochemical　properties　of　the　prepared　catalysts　were　investigated　by　XRD,　XPS　and　HR-TEM,　and　the　electrochemical　performances　of　the　catalysts　were　analyzed　by　cyclic　voltammetry　(CV),　chronoamperometry　(CA),　linear　sweep　voltammetry　(LSV),　Tafel　curve　and　electrochemical　impedance　spectroscopy　(EIS).　The　results　indicate　that　the　significantly　improved　electrocatalytic　activity　and　stability　in　alkaline　medium　for　Pd/CoO-NiO/C　catalyst　due　to　the　well　dispersed　Pd　nanoparticles　and　the　synergistic　effect　of　(Co,　Ni)O　solid　solution.　It　is　highlighted　that　Pd/CoO-NiO/C　catalyst　exhibits　a　higher　mass　peak　current　density　(2980.83　mA　mg(Pd)(-1))　than　that　of　Pd/CoO/C　(2373.75　mA　mg(Pd)(-1)　)　and　Pd/C　(1633.75　mA　mg(Pd)(-1)).　Moreover,　the　physical　origin　of　the　improved　electrocatalytic　activity　has　been　unraveled　by　first-principle　calculations.　Notably　that,　Pd-4/CoO-NiO(111)　catalyst　exhibits　more　negative　CO　adsorption　energies　E-ads　and　provides　more　electrons　during　the　CO　adsorption　process　compared　with　Pd-4/CoO(111),　which　well　explains　experimental　results.　These　results　support　that　Pd/CoO-NiO/C　catalysts　have　high　potential　for　direct　alcohol　fuel　cells　application.　(C)　2022　Elsevier　Ltd.　All　rights　reserved.