Hexa-BODIPY-cyclotriphosphazene based nanoparticle for NIR fluorescence/photoacoustic dual-modal imaging and photothermal cancer therapy - Details

author：

Indexed by：

Abstract：

Theranostic,　which　integrates　the　diagnosis　and　tumor　treatment　in　tandem,　is　an　emerging　strategy　in　cancer　treatment.　Here,　we　report　a　novel　and　unique　theranostic　nanoparticle,　HBCP　NP,　based　on　hexa-BODIPY　cyclophosphazene　(HBCP).　Due　to　the　unique　bulky　molecular　structure　of　HBCP,　this　nanoparticle　can　simultaneously　perform　near-infrared　(NIR)　fluorescence　imaging　and　photoacoustic　imaging　(PAI).　Interestingly,　since　reactive　oxygen　species　(ROS)　generation　of　HBCP　NPs　is　completely　inhibited,　‘safe’　fluorescence　imaging　is　possible　without　the　risk　of　cell　damage　even　under　laser　irradiation.　Finally,　NIR　fluorescence　imaging　and　PAI　in　4T1　tumor-bearing　mice　demonstrated　selective　accumulation　of　HBCP　NPs　at　tumor　sites.　In　addition,　HBCP　NPs　exhibited　excellent　photothermal　effects　under　high-power　laser　irradiation,　achieving　effective　tumor　growth　inhibition.　©　2022　Elsevier　B.V.

Keyword：

Diagnosis Diseases Fluorescence imaging High power lasers Infrared devices Irradiation Mammals Nanoparticles Oncology Tumors

Community：

[ 1 ] [Kwon, Nahyun]Department of Chemistry and Nano Science, Ewha Womans University, Seoul; 03760, Korea, Republic of
[ 2 ] [Kim, Kwang H.]Severance Biomedical Science Institute, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul; 03722, Korea, Republic of
[ 3 ] [Park, Sinyoung]Departments of Electrical Engineering, Mechanical Engineering, Convergence IT Engineering, Interdisciplinary Bioscience and Bioengineering, Graduate School of Artificial Intelligence, Medical Device Innovation Center, Pohang University of Science and Technology (POSTECH), Pohang; 37673, Korea, Republic of
[ 4 ] [Cho, Yejin]Severance Biomedical Science Institute, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul; 03722, Korea, Republic of
[ 5 ] [Park, Eun-Yeong]Departments of Electrical Engineering, Mechanical Engineering, Convergence IT Engineering, Interdisciplinary Bioscience and Bioengineering, Graduate School of Artificial Intelligence, Medical Device Innovation Center, Pohang University of Science and Technology (POSTECH), Pohang; 37673, Korea, Republic of
[ 6 ] [Lim, Junha]Department of Chemistry, POSTECH-CATHOLIC Biomedical Engineering Institute, Pohang University of Science and Technology (POSTECH), Pohang; 37673, Korea, Republic of
[ 7 ] [Çetindere, Seda]Department of Chemistry, Gebze Technical University, Gebze; Kocaeli; 41400, Turkey
[ 8 ] [Tümay, Süreyya Ouz]Department of Chemistry, Gebze Technical University, Gebze; Kocaeli; 41400, Turkey
[ 9 ] [Kim, Won Jong]Department of Chemistry, POSTECH-CATHOLIC Biomedical Engineering Institute, Pohang University of Science and Technology (POSTECH), Pohang; 37673, Korea, Republic of
[ 10 ] [Li, Xingshu]College of Chemistry, State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou; 350108, China
[ 11 ] [Nam, Ki Taek]Severance Biomedical Science Institute, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul; 03722, Korea, Republic of
[ 12 ] [Kim, Chulhong]Departments of Electrical Engineering, Mechanical Engineering, Convergence IT Engineering, Interdisciplinary Bioscience and Bioengineering, Graduate School of Artificial Intelligence, Medical Device Innovation Center, Pohang University of Science and Technology (POSTECH), Pohang; 37673, Korea, Republic of
[ 13 ] [Yeilot, Serkan]Department of Chemistry, Gebze Technical University, Gebze; Kocaeli; 41400, Turkey
[ 14 ] [Yoon, Juyoung]Department of Chemistry and Nano Science, Ewha Womans University, Seoul; 03760, Korea, Republic of

Reprint 's Address：

Email：

Show more details

Related Keywords：

1,2,4-Triaminobenzene as a Fluorescent Probe for Intracellular pH Imaging and Point-of-Care Ammonia Sensing
2021，ACS Applied Bio Materials
Covalent organic framework-based solid phase microextraction coupled with electrospray ionization mass spectrometry for the quantitative assessment of abnormal bile acids by triclosan exposure in mice
2025，Talanta
Lesion segmentation and identification of breast tumor on dynamic contrast-enhanced magnetic resonance imaging
2014，Journal of Shanghai Jiaotong University (Science)
Identification of macrophages in breast tumor microenvironment using label-free multiphoton microscopy
2019，Optics in Health Care and Biomedical Optics IX 2019
Plasmonic gold nanoagents for cancer imaging and therapy
2021，VIEW

Source ：

Biosensors and Bioelectronics

ISSN： 0956-5663

Year： 2022

Volume： 216

1 2 . 6

JCR@2022

1 0 . 7 0 0

JCR@2023

ESI HC Threshold：74

JCR Journal Grade：1

CAS Journal Grade：1

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count： 28

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 2

Affiliated Colleges：

Get Fulltext

DOI Library Discovery Baidu Scholar Search Engineering Village

Type
Departments

All Years Choose Year From to