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Abstract:
Ionic 1,4-difunctionalization of 1,3-enynes has often been conducted with strong nucleophiles or 1,3-enynes that are activated by an electron-withdrawing group. In this work, a palladium-catalyzed three-component ionic 1,4-carboarylation of 1,3-enynes is reported with arylated 1,3-enynes as the substrates. This method can afford various tetrasubstituted allenes with different functionalities. The palladium salt might play a key dual role in the reaction: as the catalyst to catalyze the cross-coupling reaction and as a Lewis acid to facilitate the nucleophilic attack. The synthetic value of this method is demonstrated by the further cyclization, decoration, and hydrolysis of the allene products.
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SYNTHESIS-STUTTGART
ISSN: 0039-7881
Year: 2022
Issue: 16
Volume: 54
Page: 3631-3641
2 . 6
JCR@2022
2 . 2 0 0
JCR@2023
ESI Discipline: CHEMISTRY;
ESI HC Threshold:74
JCR Journal Grade:2
CAS Journal Grade:3
Cited Count:
SCOPUS Cited Count:
ESI Highly Cited Papers on the List: 0 Unfold All
WanFang Cited Count:
Chinese Cited Count:
30 Days PV: 1
Affiliated Colleges: