A zinc-catalyzed synthesis of 3-trifluoromethyl-4-trifluoroacetyl pyrazoles - Details

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Abstract：

An　efficient　and　general　method　for　the　synthesis　of　3-trifluoromethyl-4‑trifluoroacetyl　pyrazoles　from　the　cycloaddition　of　sydnones　with　1,1,1,5,5,5-hexafluoropentane-2,4-dione　has　been　established.　Using　ZnI2/bpy　as　a　catalyst　in　THF,　this　protocol　proved　to　be　general　to　prepare　a　variety　of　3-trifluoromethyl-4‑trifluoroacetyl　pyrazoles　in　good　yields.　Utility　of　this　method　was　demonstrated　by　further　transformations　of　the　trifluoroacetyl　moiety　providing　convenient　access　to　3‑trifluoromethyl　pyrazole-based　carboxylic　acid　and　alcohol　derivatives.　©　2022　Elsevier　Ltd

Keyword：

Cycloaddition Pyrazoles Sydnones Synthetic methods Trifluoromethylation

Community：

[ 1 ] [Hong, B.]Fujian Engineering Research Center of New Chinese Lacquer Material, College of Materials and Chemical Engineering, Minjiang University, Fuzhou, 350108, China
[ 2 ] [Ding, X.]Key Laboratory of Molecule Synthesis and Function Discovery, and Fujian Provincial Key Laboratory of Electrochemical Energy Storage Materials, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 3 ] [Jiang, M.]Fujian Engineering Research Center of New Chinese Lacquer Material, College of Materials and Chemical Engineering, Minjiang University, Fuzhou, 350108, China
[ 4 ] [Qin, L.]Fujian Engineering Research Center of New Chinese Lacquer Material, College of Materials and Chemical Engineering, Minjiang University, Fuzhou, 350108, China
[ 5 ] [Lin, Z.]Fujian Engineering Research Center of New Chinese Lacquer Material, College of Materials and Chemical Engineering, Minjiang University, Fuzhou, 350108, China
[ 6 ] [Wu, W.]Fujian Engineering Research Center of New Chinese Lacquer Material, College of Materials and Chemical Engineering, Minjiang University, Fuzhou, 350108, China
[ 7 ] [Weng, Z.]Fujian Engineering Research Center of New Chinese Lacquer Material, College of Materials and Chemical Engineering, Minjiang University, Fuzhou, 350108, China
[ 8 ] [Weng, Z.]Key Laboratory of Molecule Synthesis and Function Discovery, and Fujian Provincial Key Laboratory of Electrochemical Energy Storage Materials, College of Chemistry, Fuzhou University, Fuzhou, 350108, China

Reprint 's Address：

[Weng, Z.]Fujian Engineering Research Center of New Chinese Lacquer Material, China

Email：

zweng@mju.edu.cn

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Related Keywords：

A zinc-catalyzed synthesis of 3-trifluoromethyl-4-trifluoroacetyl pyrazoles
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Source ：

Tetrahedron Letters

ISSN： 0040-4039

Year： 2022

Volume： 104

1 . 8

JCR@2022

1 . 5 0 0

JCR@2023

ESI HC Threshold：74

JCR Journal Grade：3

CAS Journal Grade：4

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count：

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 2

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