Synthesis of 3-substituted 2-trifluomethyl imidazo[1,2-a]pyridine through [3+2] cycloaddition of pyridinium ylide with trifluoroacetonitrile - Details

author：

Hong, Biqiong (Hong, Biqiong.) ^[1] | Lin, Bo (Lin, Bo.) ^[2] | Yao, Yunfei (Yao, Yunfei.) ^[3] | Li, Sailan (Li, Sailan.) ^[4] | Weng, Zhiqiang (Weng, Zhiqiang.) ^[5]

Indexed by：

Scopus SCIE

Abstract：

A　general　approach　to　prepare　2-trifluoromethyl　imidazo[1,2-a]pyridines　by　a　[3+2]　cycloaddition　of　pyridinium　ylide　with　trifluoroacetonitrile　is　described.　By　using　2,2,2-trifluoroacetaldehyde　O-(aryl)　oxime　as　convenient　precursor　of　trifluoroacetonitrile,　the　reaction　exhibits　a　broad　substrate　scope　of　pyridinium　ylides.　The　process　is　a　scalable　method　for　the　synthesis　of　potentially　bioactive　class　of　2-trifluoromethyl　imidazo[1,2-a]pyridines.　(c)　2022　Elsevier　Ltd.　All　rights　reserved.

Keyword：

2-a]pyridines Cycloaddition Imidazo[1 Synthetic methods Trifluomethylation Trifluoroacetonitrile

Community：

[ 1 ] [Hong, Biqiong]Minjiang Univ, Coll Mat & Chem Engn, Fujian Engn Res Ctr New Chinese Lacquer Mat, Fuzhou 350108, Peoples R China
[ 2 ] [Li, Sailan]Minjiang Univ, Coll Mat & Chem Engn, Fujian Engn Res Ctr New Chinese Lacquer Mat, Fuzhou 350108, Peoples R China
[ 3 ] [Weng, Zhiqiang]Minjiang Univ, Coll Mat & Chem Engn, Fujian Engn Res Ctr New Chinese Lacquer Mat, Fuzhou 350108, Peoples R China
[ 4 ] [Lin, Bo]Fuzhou Univ, Coll Chem, Key Lab Mol Synth & Funct Discovery, Fuzhou 350108, Peoples R China
[ 5 ] [Yao, Yunfei]Fuzhou Univ, Coll Chem, Key Lab Mol Synth & Funct Discovery, Fuzhou 350108, Peoples R China
[ 6 ] [Weng, Zhiqiang]Fuzhou Univ, Coll Chem, Key Lab Mol Synth & Funct Discovery, Fuzhou 350108, Peoples R China
[ 7 ] [Lin, Bo]Fuzhou Univ, Coll Chem, Fujian Prov Key Lab Electrochem Energy Storage Mat, Fuzhou 350108, Peoples R China
[ 8 ] [Yao, Yunfei]Fuzhou Univ, Coll Chem, Fujian Prov Key Lab Electrochem Energy Storage Mat, Fuzhou 350108, Peoples R China
[ 9 ] [Weng, Zhiqiang]Fuzhou Univ, Coll Chem, Fujian Prov Key Lab Electrochem Energy Storage Mat, Fuzhou 350108, Peoples R China

Reprint 's Address：

Email：

zweng@fzu.edu.cn

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Version：

Synthesis of 3-substituted 2-trifluomethyl imidazo[1,2-a]pyridine through [3+2] cycloaddition of pyridinium ylide with trifluoroacetonitrile
2022，Tetrahedron Letters

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Source ：

TETRAHEDRON LETTERS

ISSN： 0040-4039

Year： 2022

Volume： 111

1 . 8

JCR@2022

1 . 5 0 0

JCR@2023

ESI Discipline： CHEMISTRY;

ESI HC Threshold：74

JCR Journal Grade：3

CAS Journal Grade：4

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count： 4

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 1

Affiliated Colleges：

化学学院本学院/部未明确归属的数据

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