Although　specific　responsive　theranostics　biomaterials　were　essencial　for　precision　medicine,　the　univariate　responsive　strategy　was　restricted　by　high　false-positive　rates.　Herein,　we　designed　a　novel　phthalocyanine-iron-based　complex　FeS2@PcD,　as　a　theranostics　nanoreactor,　which　was　program-regulated　by　bivariate　factors　of　H+　and　H2O2　in　tumor　microenvironment　(TME).　We　found　that　FeS2@PcD　had　the　excellent　capability　of　tumor　fluorescence　imaging　(FLI),　with　a　52.21-fold　increase　in　fluorescence　signal　by　the　programmable　response,　while　the　signal　of　the　univariate　factor　was　almost　unchanged.　We　also　revealed　that　FeS2@PcD　reacted　with　H+　to　release　PcD　and　produced　Fe2+,　then　Fe2+　was　further　oxidized　by　H2O2　to　produce　Fe3+,　finally　recovering　the　fluorescence　of　PcD　whose　fluorescence　activity　was　significantly　suppressed　due　to　the　photoinduced　electron　transfer　(PET)　effect.　Notably,　except　for　fluorescence　signal,　magnetic　resonance　(MR)　signal　and　sonosensitive　activity　of　FeS2@PcD　also　changed　from　＂OFF＂　state　to　＂ON＂　state　under　the　programmable　regulation　of　H+　and　H2O2.　The　program-regulated　strategy　based　on　FeS2@PcD　realized　specific　fluorescence　and　MR　dual-modality　imaging-guided　sono/chemodynamic　therapies,　representing　a　promising　precision　medicine　approach.