In　this　study,　Bi2MoO6/FeVO4　core–shell　heterojunction　was　adopted　as　sonophotocatalyst　to　investigate　its　sonophotocatalytic　degradation　of　ciprofloxacin　(CIP)　under　ultrasonic　and　visible　light.　The　properties　of　Bi2MoO6/FeVO4　sonophotocatalyst　were　analyzed　by　XRD,　FTIR,　SEM,　TEM,　BET,　DRS,　XPS,　PL　and　EIS.　The　effects　of　different　operating　parameters　on　the　sonophotocatalytic　degradation　performance　of　CIP　were　investigated.　Under　the　optimal　operating　conditions,　a　CIP　degradation　efficiency　of　98.2　%　and　a　mineralization　rate　of　68.9　%　could　be　achieved　after　60　min　of　reaction.　Kinetic　studies　showed　that　the　degradation　process　obeyed　a　pseudo-first-order　reaction　with　a　rate　constant　of　ksonophotocatalytic　＞　kphotocatalytic　＞　ksonocatalytic.　Before　and　after　the　addition　of　H2O2,　the　sonophotocatalytic　degradation　of　CIP　reached　high　synergy　values　of　2.02　and　2.50,　respectively.　The　synergistic　effect　of　degradation　can　be　attributed　to　the　generation　of　[rad]OH,　[rad]O2−　and　h+　in　the　system.　Contribution　rate　calculation　displayed　that　[rad]OH　and　h+　were　the　most　significant　reactive　oxygen　species.　In　addition,　twenty　degradation　products　were　identified　by　HPLC-MS　analysis,　and　the　toxicity　of　the　degradation　products　was　further　analyzed　by　ECOSAR.　Ultimately,　three　potential　degradation　pathways　for　CIP　were　proposed.　©　2022　Elsevier　B.V.