Mesoporous　bioactive　glasses　(MBGs)　are　deemed　as　bone　implants　for　inducing　osteoblast　differentiation　and　preventing　bone　resorption,　however,　the　damage　of　peri-implantitis　on　soft　and　bone　tissue　has　been　generally　overlooked.　To　overcome　the　significant　antibacterial　deficiency　of　MBGs,　the　tungsten　disulfide　(WS2)　nanosheets　as　near-infrared　(NIR)　photothermal　agents　have　been　integrated　with　MBG　nanospheres　to　develop　novel　multifunctional　WS2/MBG　nanocomposites　in　this　work.　The　results　show　that　all　the　WS2/MBG　nanocomposites　exhibit　mesoporous　structures　with　larger　specific　surface　area　(up　to　475.35　m2/g))　and　more　negative　surface　zeta　potential　(−17.4　mV)　than　MBG.　Notably,　the　WS2/MBG　nanocomposites　can　effectively　promote　the　apatite　forming　ability,　the　proliferation　and　viability　of　MC3T3-E1　cells,　as　well　as　up-regulate　the　osteogenic　related　genes　expression　of　Alp,　Runx2,　Col1a1,　Opn　and　Bglap.　Moreover,　it　is　highlighted　that　the　WS2/MBG　nanocomposites　exhibit　excellent　antibacterial　efficacy　toward　S.　aureus　under　NIR　laser　irradiation,　with　the　antibacterial　rate　up　to　96.13%.　These　results　will　offer　an　appealing　strategy　to　develop　multifunctional　WS2/MBG　nanocomposites　with　enhanced　biological　activity　and　additional　antibacterial　property　for　bone　tissue　engineering.　©　Elsevier　Ltd　and　Techna　Group　S.r.l.