To　control　spontaneous　combustion　of　sulfide　ores,　the　compound　inhibitor　was　prepared　by　selecting　physical　resistance　raw　materials(Na2CO3),　chemical　resistance　raw　materials(Melatonin),　Cetyltrimethylammonium　bromide(CTMAB)　and　hydroxyethyl　cellulose(HEC).　With　the　help　of　the　simultaneous　thermal　analyzer,　different　concentrations　of　inhibitors　were　prepared　and　the　thermal　behavior　of　the　ore　samples　with　10,　15,　and　20　wt%　inhibitor　at　four　heating　rates　of　5,　10,　15,　and　20　K/min　was　determined.　The　Flynn-Wall-Ozawa　method　was　applied　to　calculate　the　activation　energy　of　sulfide　ores　with　different　concentrations.　The　results　showed　that:　Gradually　increasing　the　heating　rate　will　increase　the　reaction　intensity　of　each　ore　sample　in　the　first　weight　loss　stage　of　thermal　decomposition,　and　then　reduce　the　mass　of　the　ore　samples　involved　in　the　second　weight　loss　stage;　The　thermal　stability　of　each　resisted　ore　sample　is　better　than　that　of　the　original　ore　sample;　The　increase　in　the　concentration　of　inhibitor　can　inert　the　reaction　process　of　ore　samples　in　the　thermal　decomposition　stage,　weakening　the　exothermic　effect　of　ore　samples;　The　inhibitor　with　15　wt%　had　a　better　effect　on　preventing　spontaneous　combustion　of　sulfide　ores,　and　its　property　value　is　higher　than　other　concentrations.