Instead　of　the　conventional　perception　of　nitrous　oxide　(N2O)　as　a　potent　greenhouse　gas　whose　production　should　be　minimized,　this　work　aimed　to　assess　N2O　recovery　as　a　potential　energy　source　from　nitric　oxide　(NO)　in　the　form　of　Fe(II)EDTA-NO　through　element　sulfur　(S0)　or　thiosulfate　(S2O32−)-driven　NO-based　autotrophic　denitrification　(SNADS0　or　SNADS2O3).　A　mathematical　model　was　proposed　to　describe　substrate　dynamics　related　to　N2O　production　and　reduction　and　was　successfully　calibrated　and　validated　using　batch　experimental　data　from　lab-scale　SNADS0　and　SNADS2O3　systems　under　different　substrates　conditions.　The　model　was　subsequently　employed　to　assess　the　potential　of　N2O　accumulation　and　recovery　by　altering　the　S/N　mass　ratio　and　the　ratio　of　gas　volume　to　liquid　volume　of　the　system.　The　simulation　results　suggested　that　with　a　S/N　mass　ratio　of　nearly　1.0,　high-purity　N2O　could　be　more　rapidly　and　efficiently　recovered　from　Fe(II)EDTA-NO　in　the　SNADS0　and　SNADS2O3　systems　with　a　higher　ratio　of　gas　volume　to　liquid　volume　(i.e.,　a　N2O　recovery　efficiency　of　up　to　80.2%−84.9%　reached　within　3.1　h−3.5　h　under　the　studied　conditions).　Comparatively,　the　SNADS0　process　showed　an　economic　and　viable　advantage　for　practical　applications　to　the　efficient　treatment　and　resource　utilization　of　NO-containing　flue　gas.　©　2022　Elsevier　B.V.