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author：

Ma, X.-Y. (Ma, X.-Y..) [1] | Zhang, W. (Zhang, W..) [2] | Que, R.-B. (Que, R.-B..) [3] | Wang, C. (Wang, C..) [4] | Shang, W.-W. (Shang, W.-W..) [5] | Zhu, Y.-Y. (Zhu, Y.-Y..) [6] | Zheng, B.-Y. (Zheng, B.-Y..) [7] | Chen, Y. (Chen, Y..) [8] | Ke, M.-R. (Ke, M.-R..) [9] | Huang, J.-D. (Huang, J.-D..) [10]

Indexed by：

Scopus

Abstract：

This　work　reports　the　development　of　a　multifunctional　thermosensitive　liposomal　nanoplatform　(PcS4@Lip-FA)　based　on　a　metal-free　phthalocyanine　modified　with　tetra-sulfonates　(PcPS4),　which　exhibited　photodynamic　and　photothermal　activities　simultaneously.　Upon　irradiation　with　a　near　infrared　laser,　thermosensitive　PcS4@Lip-FA　could　release　PcS4　as　a　result　of　the　local　hyperthermia　of　PcS4.　Interestingly,　PcS4　could　easily　chelate　with　Cu2+,　leading　to　the　enhancement　of　photothermal　activity　and　decrease　of　photodynamic　activity.　In　addition,　in　vivo　fluorescence　imaging　revealed　that　PcS4@Lip-FA　could　selectively　accumulate　in　tumor　tissue　of　H22　tumor-bearing　mice　after　tail　vein　injection,　and　exhibited　a　significant　anticancer　phototherapeutic　effect,　with　a　tumor　inhibition　rate　of　83.5　%.　Therefore,　PcPS4@Lip-FA　has　realized　fluorescence　imaging-guided　combined　cancer　treatment,　providing　a　promising　multifunctional　nanoplatform　for　cancer　diagnostics　and　therapy.　©　2022　Wiley-VCH　GmbH.

Keyword：

copper liposomes photodynamic therapy photothermal therapy phthalocyanines

Community：

  • [ 1 ] [Ma, X.-Y.]Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fu Zhou, 350108, China
  • [ 2 ] [Zhang, W.]Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fu Zhou, 350108, China
  • [ 3 ] [Que, R.-B.]Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fu Zhou, 350108, China
  • [ 4 ] [Wang, C.]Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fu Zhou, 350108, China
  • [ 5 ] [Shang, W.-W.]Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fu Zhou, 350108, China
  • [ 6 ] [Zhu, Y.-Y.]Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fu Zhou, 350108, China
  • [ 7 ] [Zheng, B.-Y.]Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fu Zhou, 350108, China
  • [ 8 ] [Chen, Y.]Cancer Bio-immunotherapy Center, Fujian Medical University Cancer Hospital and Fujian Cancer Hospital, Zhou, 350000 Fu, China
  • [ 9 ] [Ke, M.-R.]Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fu Zhou, 350108, China
  • [ 10 ] [Huang, J.-D.]Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fu Zhou, 350108, China

Reprint 's Address：

  • [Ke, M.-R.]Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, China;;[Huang, J.-D.]Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, China

Email：


kemeirong@fzu.edu.cn |
jdhuang@fzu.edu.cn
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Source ：

ChemPlusChem

ISSN： 2192-6506

Year： 2022

Issue： 10

Volume： 87

3 . 4

JCR@2022

3 . 0 0 0

JCR@2023

ESI HC Threshold：74

JCR Journal Grade：2

CAS Journal Grade：4

Cited Count：

WoS CC Cited Count： 0

SCOPUS Cited Count： 1

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 2

Affiliated Colleges：

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