This　work　reports　the　development　of　a　multifunctional　thermosensitive　liposomal　nanoplatform　(PcS4@Lip-FA)　based　on　a　metal-free　phthalocyanine　modified　with　tetra-sulfonates　(PcPS4),　which　exhibited　photodynamic　and　photothermal　activities　simultaneously.　Upon　irradiation　with　a　near　infrared　laser,　thermosensitive　PcS4@Lip-FA　could　release　PcS4　as　a　result　of　the　local　hyperthermia　of　PcS4.　Interestingly,　PcS4　could　easily　chelate　with　Cu2+,　leading　to　the　enhancement　of　photothermal　activity　and　decrease　of　photodynamic　activity.　In　addition,　in　vivo　fluorescence　imaging　revealed　that　PcS4@Lip-FA　could　selectively　accumulate　in　tumor　tissue　of　H22　tumor-bearing　mice　after　tail　vein　injection,　and　exhibited　a　significant　anticancer　phototherapeutic　effect,　with　a　tumor　inhibition　rate　of　83.5　%.　Therefore,　PcPS4@Lip-FA　has　realized　fluorescence　imaging-guided　combined　cancer　treatment,　providing　a　promising　multifunctional　nanoplatform　for　cancer　diagnostics　and　therapy.