Recently,　the　nitrate/nitrite-dependent　anaerobic　methane　oxidation　(n-DAMO)　processes　have　become　a　research　hotspot　in　the　field　of　wastewater　treatment.　The　n-DAMO　processes　could　not　only　mitigate　direct　and　indirect　carbon　emissions　from　wastewater　treatment　plants　but　also　strengthen　biological　nitrogen　removal.　However,　the　applications　of　n-DAMO-based　biotechnologies　face　practical　difficulties　mainly　caused　by　the　distinctive　properties　of　n-DAMO　microorganisms　and　the　limited/availability　of　methane　with　poor　solubility.　In　this　sense,　the　choice　of　bioreactors　will　play　important　roles　that　influence　the　growth　and　functioning　of　n-DAMO　microorganisms,　thus　enabling　dedicated　development　of　the　n-DAMO　processes　and　efficient　applications　of　n-DAMO-based　biotechnologies.　Therefore,　this　paper　aims　to　discuss　the　three　commonly-applied　types　of　bioreactors,　covering　the　individual　working　principle　and　state-of-the-art　removal　performance　of　nitrogen　as　well　as　dissolved　methane　observed　when　adopted　for　n-DAMO-based　biotechnologies.　With　noted　limitations　for　each　bioreactor　type,　several　key　perspectives　were　proposed　which　hopefully　would　inspire　future　investigation　and　practical　applications　of　the　n-DAMO　processes.　©　2022　Elsevier　B.V.