Synthesising　a　heterojunction　structure　with　a　tight　interface　and　sufficient　contact　area　is　critical　for　yielding　photogenerated　carriers　with　superior　migration　efficiencies;　however,　this　remains　a　significant　challenge.　Herein,　zeolitic　imidazolate　framework-67　(ZIF-67)　was　synthesised　via　four　different　methods.　Using　methanol　as　the　medium,　the　as-prepared　ZIF-67　(denoted　as　ZM)　exhibited　a　uniform　morphology　and　good　crystallinity.　Subsequently,　a　well-designed　step-scheme　(S-scheme)　CdS@ZM　heterojunction　was　fabricated　via　the　in-situ　coating　of　CdS　quantum　dots　(QDs)　on　the　ZM　dodecahedrons.　We　utilized　the　exposed　Co　centres　in　the　ZM　as　the　“trapping　baits”　to　anchor　S2–　precursors　and　yield　a　highly　dispersed　CdS　QD　coating.　Owing　to　the　in-situ　coating　of　CdS　QDs,　the　obtained　S-scheme　CdS@ZM　composites　exhibited　excellent　interfacial　contacts　and　uniform　morphological　distributions.　Under　visible　light　irradiation　(λ　≥　420　nm),　the　40%CdS@ZM　heterojunctions　displayed　an　excellent　photocatalytic　sterilisation　rate　of　97.6　%　within　15　min　in　the　disinfection　of　Staphylococcus　aureus,　which　was　higher　than　those　of　pure　ZM　(51.0　%)　and　CdS　(21.9　%).　Finally,　the　S-scheme　charge　transfer　pathway　of　CdS@ZM　was　confirmed　using　X-ray　photoelectron　spectroscopy,　scanning　Kelvin　probe　microscopy,　and　electron　spin　resonance　analyses.　©　2022　Elsevier　B.V.