Antibiotics　in　the　aquatic　environments　pose　a　severe　threat　to　global　public　health.　Hence,　a　sonophotocatalytic　membrane　reactor　(SPMR)　of　sonophotocatalysis　coupled　membrane　separation　was　designed　to　realize　continuous　and　stable　degradation　of　ciprofloxacin　(CIP)　by　Bi2MoO6/FeVO4　in　this　study.　The　prepared　catalysts　were　characterized　by　XRD,　SEM,　TEM,　BET,　UV-vis　DRS,　PL,　and　EIS.　Under　the　optimal　hydraulic　retention　time　(HRT)　of　55　min,　93.43%　of　CIP　(10　mg/L)　was　degraded　by　Bi2MoO6/FeVO4　(500　mg/L)　after　200　min　sonophotocatalytic　reaction　in　the　presence　of　H2O2　(20　mM).　The　synergy　index　(SI)　of　sonocatalysis　and　photocatalysis　was　calculated　to　1.80　during　the　catalytic　process.　The　SPMR　effluent　turbidity　was　basically　nil　after　10　min　separation　of　catalyst　by　polyvinylidene　fluoride　(PVDF)　hollow　fiber　membrane.　The　changes　of　PVDF　membrane　before　and　after　use　in　SPMR　were　observed　by　SEM　and　FTIR.　The　membrane　fouling　behavior　in　the　SPMR　was　investigated　by　membrane　water　flux,　flux　recovery　rate,　and　membrane　resistances.　The　mechanisms　of　CIP　degradation　are　attributed　to·OH　and·holes　(h+)　generated　by　Bi2MoO6/FeVO4　under　ultrasonic　and　visible　light　irradiation.　Besides,　the　solution　matrix　effects　on　sonophotocatalytic　removal　of　CIP　were　investigated.　The　results　proved　that　SPMR　still　maintained　satisfactory　sonophotocatalytic　degradation　efficiency　in　typical　natural　water　bodies　and　simulated　water　matrices.　In　this　work,　the　continuous　operation　process　of　CIP　degradation　and　catalyst　separation　was　realized,　and　the　membrane　fouling　was　alleviated　by　ultrasonic.　©　2022　Elsevier　Ltd.