The　rhizome　of　Polygonatum　sibiricum　is　a　traditional　Chinese　medicine　material　and　also　a　popular　functional　food　consumed　in　China.　Due　to　the　increasing　demand　and　overexploitation,　the　use　of　the　cultivated　plant　is　growing　rapidly.　However,　the　difference　in　phytochemical　profile　and　health　benefit　between　the　cultivated　and　wild-grown　P.　sibiricum　has　not　been　revealed　yet.　The　objectives　of　this　study　are　to　compare　the　phytochemical　profiles　of　two　types　of　P.　sibiricum,　i.e.,　the　cultivated　and　the　wild-grown　types,　by　using　UHPLC-Q-Orbitrap-MS　based　untargeted　metabolomics　approach.　We　tentatively　identified　190　phytochemicals　belonging　to　alkaloids,　flavonoids,　phenolic　acids,　and　terpenoids　from　both　two　types　of　samples.　In　general,　there　is　distinctive　difference　in　phytochemical　profiles　between　these　two　types　of　samples.　Specifically,　33　phytochemicals　showed　significant　differences.　Of　these　phytochemicals,　22　compounds,　such　as　laetanine,　p-coumaroyl-beta-D-glucose,　geniposide,　medicagenic　acid,　were　significantly　higher　in　cultivated　type;　11　compounds,　such　as　vicenin-2,　kaempferol　7-neohesperidoside,　vanillic　acid,　and　obacunone,　were　significantly　higher　in　wild-grown　type　samples.　This　study　will　expand　our　knowledge　regarding　the　cultivated　of　P.　sibiricum　and　facilitate　its　further　application　in　pharmaceutical　and　food　industries.