Piezocatalysis,　governed　by　piezo-potential　within　piezoelectrics,　has　gained　prominence　for　reactive　oxygen　species　(ROS)　generation,　which　is　significant　to　environmental　and　biological　applications.　However,　designing　piezocatalysts　with　excellent　piezocatalytic　performance　in　a　wide　temperature　and　efficient　charge　carrier　separation　ability　is　still　challenging.　Herein,　eco-friendly　BaTiO3　(BT)-based　perovskite　ferroelectrics　with　tailored　multiphase　coexistence　in　a　wide　temperature　range　are　constructed　to　boost　higher　piezoelectricity　and　large　piezo-potential,　which　is　attributed　to　decreased　polarization　anisotropy　by　flat　Gibbs　energy　profile.　Elevated　piezo-potential　in　designed　BT-based　piezocatalyst　guarantees　high-efficient　generation　rate　of　center　dot　OH　(200　mu　mol　g(-1)　h(-1))　and　center　dot　O-2(-)　(40　mu　mol　g(-1)　h(-1))　by　ultrasound　stimulation,　which　is　3.5　times　more　than　that　of　pure　BT.　Besides,　piezocatalytic　capacity　to　degrade　dye　wastewater　shows　a　rate　constant　of　0.0182　min(-1)　and　gives　an　antibacterial　rate　of　95%　within　30　min　for　eliminating　E.　coli.　Theoretical　simulations　validate　that　the　local　distortion　of　TiO6　octahedra　also　contributes　to　piezocatalytic　performance　by　inducing　electron-hole　pairs　separation　in　real　space,　and　better　response　to　slight　structural　deformation.　This　work　is　important　to　design　high-performance　piezocatalysts　with　high-efficiency　ROS　generation　for　sewage　treatment　and　sonodynamic　therapy.