Background:　Drug-resistant　microbes　pose　a　global　health　concern,　requiring　the　urgent　development　of　effective　antibacterial　agents　and　strategies　in　clinical　practice.　Therefore,　there　is　an　urgent　need　to　explore　novel　antibacterial　materials　to　effectively　eliminate　bacteria.　The　synthesis　of　quaternary　phosphonium　salt　in　haloargentate　systems,　wherein　the　phosphorus　atom　is　represented　in　a　cationic　form,　is　a　possible　strategy　for　the　development　of　antibacterial　materials.Methods:　Using　(triphenyl)phosphonium-based　quaternary　phosphorus　salts　with　different　spacer　lengths　(n=2,　4,　6)　as　a　template,　we　designed　three　kinds　of　quaternary　phosphorus　salts　as　effective　antibacterial　agents　against　drug-resistant　bacteria.Results:　The　synthesized　quaternary　phosphorus　salt　of　(1,4-DBTPP)Br2　effectively　prevented　the　formation　of　the　bacterial　biofilms,　and　degraded　bacterial　membranes　and　cell　walls　by　promoting　the　production　of　reactive　oxygen　species,　which　exhibited　effective　therapeutic　effects　in　a　rat　model　of　a　superficial　wound　infected　with　methicillin-resistant　Staphylococcus　aureus.　Conclusion:　The　quaternary　phosphorus　salt　(1,4-DBTPP)Br2　demonstrated　hemocompatibility　and　low　toxicity,　revealing　its　potential　in　the　treatment　of　clinical　infections.