Managing　chronic　non-healing　wounds　presents　a　significant　clinical　challenge　due　to　their　frequent　bacterial　infections.　Mesoporous　silica-based　materials　possess　robust　wound-healing　capabilities　attributed　to　their　renowned　antimicrobial　properties.　The　current　study　details　the　advancement　of　mesoporous　silicon-loaded　MnO　and　CaO　molecules　(HMn-Ca)　against　bacterial　infections　and　chronic　non-healing　wounds.　HMn-Ca　was　synthesized　by　reducing　manganese　chloride　and　calcium　chloride　by　urotropine　solution　with　mesoporous　silicon　as　the　template,　thereby　transforming　the　manganese　and　calcium　ions　on　the　framework　of　mesoporous　silicon.　The　developed　HMn-Ca　was　investigated　using　scanning　electron　microscopy　(SEM),　transmission　electron　microscope　(TEM),　ultraviolet-visible　(UV-visible),　and　visible　spectrophotometry,　followed　by　the　determination　of　Zeta　potential.　The　production　of　reactive　oxygen　species　(ROS)　was　determined　by　using　the　3,3,5,5-tetramethylbenzidine　(TMB)　oxidation　reaction.　The　wound　healing　effectiveness　of　the　synthesized　HMn-Ca　is　evaluated　in　a　bacterial-infected　mouse　model.　The　loading　of　MnO　and　CaO　inside　mesoporous　silicon　enhanced　the　generation　of　ROS　and　the　capacity　of　bacterial　capture,　subsequently　decomposing　the　bacterial　membrane,　leading　to　the　puncturing　of　the　bacterial　membrane,　followed　by　cellular　demise.　As　a　result,　treatment　with　HMn-Ca　could　improve　the　healing　of　the　bacterial-infected　wound,　illustrating　a　straightforward　yet　potent　method　for　engineering　nanozymes　tailored　for　antibacterial　therapy.