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Abstract：
Theranostic, which integrates the diagnosis and tumor treatment in tandem, is an emerging strategy in cancer treatment. Here, we report a novel and unique theranostic nanoparticle, HBCP NP, based on hexa-BODIPY cyclophosphazene (HBCP). Due to the unique bulky molecular structure of HBCP, this nanoparticle can simultaneously perform near-infrared (NIR) fluorescence imaging and photoacoustic imaging (PAI). Interestingly, since reactive oxygen species (ROS) generation of HBCP NPs is completely inhibited, `safe＇ fluorescence imaging is possible without the risk of cell damage even under laser irradiation. Finally, NIR fluorescence imaging and PAI in 4T1 tumor-bearing mice demonstrated selective accumulation of HBCP NPs at tumor sites. In addition, HBCP NPs exhibited excellent photothermal effects under high-power laser irradiation, achieving effective tumor growth inhibition.
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BIOSENSORS & BIOELECTRONICS
ISSN： 0956-5663
Year： 2022
Volume： 216
1 2 . 6
JCR@2022
1 0 . 7 0 0
JCR@2023
ESI Discipline： CHEMISTRY;
ESI HC Threshold：74
JCR Journal Grade：1
CAS Journal Grade：1
Cited Count：
WoS CC Cited Count： 17
SCOPUS Cited Count： 28
ESI Highly Cited Papers on the List： 0 Unfold All
WanFang Cited Count：
Chinese Cited Count：
30 Days PV： 3
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