As　a　novel　lightweight　metallic　structure,　metal　rubber　seals　(MRS)　can　be　used　for　sealing　elements　in　extreme　environments　where　traditional　polymer　rubber　seals　become　ineffective.　In　the　present　work,　a　virtual　fabrication　technology　(VFT)　of　MRS　based　on　computer-aided　simulation　technology　was　developed　to　accurately　reflect　the　random　contact　interface　behavior　between　the　disordered　spiral　network　structure　of　MRS　core　and　metal　sheet.　The　mechanical　properties　(meso　contact　characteristics　and　macro　structural　response)　of　the　complex　structure　were　characterized　by　numerical　analysis　and　compressive　tests.　The　effect　of　the　compression　ratio　and　material　porosity　on　contact　pressure　performances　of　sealing　interface　was　analyzed　in　detail.　It　is　found　that　the　meso　contact　pressure　of　MRS　is　affected　by　the　joint　action　of　compression　condition,　inner　core　support　and　cladding　failure.　There　is　a　turning　point　in　a　certain　range,　which　allow　the　MRS　prepared　in　this　work　has　the　relatively　best　contact　characteristics　when　the　porosity　is　51.5%　and　the　compression　condition　is　15%.　The　force-displacement　curves　obtained　from　simulation　and　experiment　both　exhibit　an　obvious　nonlinearity　and　slow　growth　area,　which　confirm　that　the　MRS　constitutive　model　based　on　VFT　can　effectively　characterize　the　multi-scale　conformity　of　MRS　specimens　from　meso-structure　to　macro-performance.　©　2022　Taylor　&　Francis　Group,　LLC.