With　the　development　of　modern　technology,　flexible　human-machine　interaction,　artificial　intelligence,　portable　detection,　and　other　emerging　fields　have　been　built　up.　The　demand　for　high　flexibility　in　these　fields　leads　to　flexible　pressure　sensors　getting　more　and　more　attention.　Using　flexible　materials　can　enable　them　to　realize　the　pressure　sensing　function　while　giving　them　lighter　weight,　smaller　size,　and　better　deformation　ability.　These　characteristics　make　flexible　pressure　sensors　can　be　widely　used　in　emerging　fields　and　have　more　longterm　development　potential.　In　recent　years,　many　technologies　have　been　devoted　to　improving　the　performance　of　flexible　pressure　sensors.　Among　them,　microstructure　engineering　is　the　most　significant　for　high-performance　flexible　sensors.　This　review　focuses　on　the　rapid　development　of　flexible　pressure　sensors　and　the　microstructure　of　high-performance　flexible　sensors.　This　article　describes　four　sensing　mechanisms:　capacitive,　resistive,　piezoelectric,　and　triboelectric.　Besides,　the　microstructure　system,　which　can　improve　the　sensitivity　of　capacitive　flexible　pressure　sensors,　is　discussed　comprehensively.　In　addition,　the　current　applications　of　the　capacitive　flexible　pressure　sensor　are　introduced.　Furthermore,　this　article　discusses　prospects　for　developing　direction　and　application　fields　of　high-performance　flexible　pressure　sensors　according　to　some　currently　developed　microstructure　technologies.　The　research　in　this　review　has　essential　foreshadowing　significance　and　reference　value　for　developing　flexible　pressure　sensors　in　various　intelligent　fields　in　the　future.　©　2022　IEEE.