Login | Cas Login
English| 简体中文| 繁体中文

  • Complex
  • Title
  • Keyword
  • Abstract
  • Scholars
  • Journal
  • ISSN
  • Conference
成果搜索

Advanced Search

author：

Zhu, Yang (Zhu, Yang.) [1] | Gong, Peng (Gong, Peng.) [2] | Wang, Jun (Wang, Jun.) [3] | Cheng, Junjie (Cheng, Junjie.) [4] | Wang, Wenyu (Wang, Wenyu.) [5] | Cai, Huilan (Cai, Huilan.) [6] | Ao, Rujiang (Ao, Rujiang.) [7] | Huang, Hongwei (Huang, Hongwei.) [8] | Yu, Meili (Yu, Meili.) [9] | Lin, Lisen (Lin, Lisen.) [10] | Chen, Xiaoyuan (Chen, Xiaoyuan.) [11]

Indexed by：

EI

Abstract：

Lipid　peroxidation　(LPO)　is　one　of　the　most　damaging　processes　in　chemodynamic　therapy　(CDT).　Although　it　is　well　known　that　polyunsaturated　fatty　acids　(PUFAs)　are　much　more　susceptible　than　saturated　or　monounsaturated　ones　to　LPO,　there　is　no　study　exploring　the　effect　of　cell　membrane　unsaturation　degree　on　CDT.　Here,　we　report　a　self-reinforcing　CDT　agent　(denoted　as　OA@Fe-SAC@EM　NPs),　consisting　of　oleanolic　acid　(OA)-loaded　iron　single-atom　catalyst　(Fe-SAC)-embedded　hollow　carbon　nanospheres　encapsulated　by　an　erythrocyte　membrane　(EM),　which　promotes　LPO　to　improve　chemodynamic　efficacy　via　modulating　the　degree　of　membrane　unsaturation.　Upon　uptake　of　OA@Fe-SAC@EM　NPs　by　cancer　cells,　Fe-SAC-catalyzed　conversion　of　endogenous　hydrogen　peroxide　into　hydroxyl　radicals,　in　addition　to　initiating　the　chemodynamic　therapeutic　process,　causes　the　dissociation　of　the　EM　shell　and　the　ensuing　release　of　OA　that　can　enrich　cellular　membranes　with　PUFAs,　enabling　LPO　amplification-enhanced　CDT.　©　2023　Wiley-VCH　GmbH.

Keyword：

Catalysts Cell membranes Cytology Lipids Nanospheres Oxidation Oxidative stress Polyunsaturated fatty acids

Community：

  • [ 1 ] [Zhu, Yang]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Engineering Technology Research Center on Reagent and Instrument for Rapid Detection of Product Quality and Food Safety in Fujian Province, College of Chemistry, Fuzhou University, Fuzhou; 350108, China
  • [ 2 ] [Zhu, Yang]Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering, and Biomedical Engineering, Yong Loo Lin School of Medicine and College of Design and Engineering, National University of Singapore, Singapore; 119074, Singapore
  • [ 3 ] [Zhu, Yang]Clinical Imaging Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; 117599, Singapore
  • [ 4 ] [Zhu, Yang]Nanomedicine Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; 117597, Singapore
  • [ 5 ] [Zhu, Yang]Institute of Molecular and Cell Biology, Agency for Science, Technology, and Research (A*STAR), 61 Biopolis Drive, Proteos, Singapore; 138673, Singapore
  • [ 6 ] [Gong, Peng]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Engineering Technology Research Center on Reagent and Instrument for Rapid Detection of Product Quality and Food Safety in Fujian Province, College of Chemistry, Fuzhou University, Fuzhou; 350108, China
  • [ 7 ] [Wang, Jun]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Engineering Technology Research Center on Reagent and Instrument for Rapid Detection of Product Quality and Food Safety in Fujian Province, College of Chemistry, Fuzhou University, Fuzhou; 350108, China
  • [ 8 ] [Cheng, Junjie]CAS Key Laboratory of Soft Matter Chemistry, University of Science and Technology of China, Hefei; 230026, China
  • [ 9 ] [Wang, Wenyu]CAS Key Laboratory of Soft Matter Chemistry, University of Science and Technology of China, Hefei; 230026, China
  • [ 10 ] [Cai, Huilan]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Engineering Technology Research Center on Reagent and Instrument for Rapid Detection of Product Quality and Food Safety in Fujian Province, College of Chemistry, Fuzhou University, Fuzhou; 350108, China
  • [ 11 ] [Ao, Rujiang]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Engineering Technology Research Center on Reagent and Instrument for Rapid Detection of Product Quality and Food Safety in Fujian Province, College of Chemistry, Fuzhou University, Fuzhou; 350108, China
  • [ 12 ] [Huang, Hongwei]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Engineering Technology Research Center on Reagent and Instrument for Rapid Detection of Product Quality and Food Safety in Fujian Province, College of Chemistry, Fuzhou University, Fuzhou; 350108, China
  • [ 13 ] [Yu, Meili]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Engineering Technology Research Center on Reagent and Instrument for Rapid Detection of Product Quality and Food Safety in Fujian Province, College of Chemistry, Fuzhou University, Fuzhou; 350108, China
  • [ 14 ] [Lin, Lisen]MOE Key Laboratory for Analytical Science of Food Safety and Biology, Engineering Technology Research Center on Reagent and Instrument for Rapid Detection of Product Quality and Food Safety in Fujian Province, College of Chemistry, Fuzhou University, Fuzhou; 350108, China
  • [ 15 ] [Chen, Xiaoyuan]Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering, and Biomedical Engineering, Yong Loo Lin School of Medicine and College of Design and Engineering, National University of Singapore, Singapore; 119074, Singapore
  • [ 16 ] [Chen, Xiaoyuan]Clinical Imaging Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; 117599, Singapore
  • [ 17 ] [Chen, Xiaoyuan]Nanomedicine Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; 117597, Singapore
  • [ 18 ] [Chen, Xiaoyuan]Institute of Molecular and Cell Biology, Agency for Science, Technology, and Research (A*STAR), 61 Biopolis Drive, Proteos, Singapore; 138673, Singapore

Reprint 's Address：

Email：

Show more details

Related Keywords：

Related Article：

Source ：

Angewandte Chemie - International Edition

ISSN： 1433-7851

Year： 2023

Issue： 12

Volume： 62

1 6 . 1

JCR@2023

1 6 . 1 0 0

JCR@2023

ESI HC Threshold：39

JCR Journal Grade：1

CAS Journal Grade：1

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count：

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 0

Affiliated Colleges：

Get Fulltext

DOI Library Discovery Baidu Scholar Search Engineering Village
Online/Total：246/10041107
Address：FZU Library(No.2 Xuyuan Road, Fuzhou, Fujian, PRC Post Code：350116) Contact Us：0591-22865326
Copyright：FZU Library Technical Support：Beijing Aegean Software Co., Ltd. 闽ICP备05005463号-1