The　demand　to　effectively　treat　medical　wastewater　has　escalated　with　the　much　greater　use　of　antiviral　drugs　since　the　COVID-19　pandemic.　Forward　osmosis　(FO)　has　great　potential　in　wastewater　treatment　only　when　appropriate　draw　solutes　are　available.　Here,　we　synthesize　a　series　of　smart　organic-inorganic　polyoxomolybdates　(POMs),　namely,　(NH4)6[Mo7O24],　(PrNH3)6[Mo7O24],　(iPrNH3)6[Mo7O24],　and　(BuNH3)6[Mo7O24],　for　FO　to　treat　antiviral-drug　wastewater.　Influential　factors　of　separation　performance　have　been　systematically　studied　by　tailoring　the　structure,　organic　characteristics,　and　cation　chain　length　of　POMs.　POMs　at　0.4　M　produce　water　fluxes　ranging　from　14.0　to　16.4　LMH　with　negligible　solute　losses,　at　least　116%　higher　than　those　of　NaCl,　NH4HCO3,　and　other　draw　solutes.　(NH4)6[Mo7O24]　creates　a　water　flux　of　11.2　LMH,　increased　by　more　than　200%　compared　to　that　of　NaCl　and　NH4HCO3　in　long-term　antiviral-drug　wastewater　reclamation.　Remarkably,　the　drugs　treated　with　NH4HCO3　and　NaCl　are　either　contaminated　or　denatured,　while　those　with　(NH4)6[Mo7O24]　remain　intact.　Moreover,　these　POMs　are　recovered　by　sunlight-assisted　acidification　owing　to　their　light　and　pH　dual　sensitivity　and　reusability　for　FO.　POMs　prove　their　suitability　as　draw　solutes　and　demonstrate　their　superiority　over　the　commonly　studied　draw　solutes　in　wastewater　treatment.　©　2023　American　Chemical　Society.